Business

Cauvery row back on the boil as CWMA orders K’taka to release 12k cusecs

CWMA orders Karnataka to release 12,000 cusecs Cauvery water daily to Tamil Nadu for 15 days from Aug 12; K’taka weighs Supreme Court move amid protests.

Tech Tuesday: Executive Appointments, New Apps

RetailMeNot is celebrating 20 years in business by launching a new "Rewards" app that is powered by AI and touts new deal, finding features.

Zepto warehouse in Bengaluru sealed over ‘extremely unhygienic’ conditions

The warehouse, operated by Nippon Express, has also been issued a notice, while the department has recommended filing a case against the facility

Relationship between initial dose, dose intensity, and survival in unresectable pancreatic cancer treated with nanoliposomal irinotecan, fluorouracil, and folinic acid

While nanoliposomal irinotecan with fluorouracil and folinic acid (NFF) is a standard second, line regimen for unresectable pancreatic cancer (uPC) after gemcitabine, based therapy, the effects of initial dosing and relative dose intensity (RDI) in routine practice are unclear. We retrospectively analyzed 161 patients (median age 67 years; 55% male) with uPC treated with NFF at 20 Japanese institutions (June 2020–May 2021), comparing standard vs. reduced starting dose and RDI ≥80% vs. <80%. Overall survival (OS) was 8.1 vs. 8.8 months for standard vs. reduced dose (p = 0.47; hazard ratio [HR], 1.15) and 7.5 vs. 9.2 months for RDI ≥80% vs. <80% (p = 0.39; HR, 0.85). Progression, free survival (PFS) was 3.4 vs. 3.2 months (p = 0.43) and 2.8 vs. 4.4 months (p = 0.13), respectively, with similar response and disease control rates. Anemia, thrombocytopenia, and vomiting occurred more frequently in patients administered the standard starting dose, whereas severe non, hematologic adverse events were more frequently observed for RDI <80%. Reduced starting dose and RDI <80% were not associated with inferior survival, suggesting that individualized dose modification may be feasible. Future prospective studies are warranted to refine NFF dosing strategies.

The Hormuz Crisis Has Forever Changed the Economics of Energy Security

Complex systems reveal their true characteristics only under stress. Disturbance exposes assumptions that routine operation conceals and becomes the catalyst for adaptation. Capital reassesses risk, governments reconsider policy, and markets establish a new equilibrium. The resulting system may ultimately prove stronger than the one that preceded it, but it is never identical. Recent developments surrounding the Strait of Hormuz provide one such moment. Whether they ultimately prove to be a lasting geopolitical inflection point remains uncertain....

Ethanol or EVs? India needs both for cleaner mobility, says IFGE

India Business News: India's shift towards cleaner mobility will require multiple technologies rather than a choice between ethanol and electric vehicles, the I...